Contents
15 March 2019
Vol 363, Issue 6432
Vol 363, Issue 6432
Special Issue
Pediatric Cancer
Introduction to special issue
News
- Beyond survival
Cancer treatment takes a toll on small bodies. As more children survive the disease, there's a push to better their health in the years ahead.
Reviews
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Scheme to mine the abyss gets sea trial
As collector robot gathers metal-rich nodules, scientists will monitor ecosystems.
- Moratorium for germline editing splits biologists
New call for ban opposed by those who say current laws and regulations are enough.
- How farming reshaped our smiles and our speech
Soft diet led to overbite in adults, favoring sounds like "f" and "v" in the languages of farming societies.
- Giant prevention study has sobering message
Mixed results suggest "ending AIDS" through treatment will be harder than expected.
- WHO is ‘changing its DNA’ in bid to meet new goals
Critics say an ambitious reform program doesn't address chronic cash shortage and other long-standing problems.
- Private sector nears rank of top Ph.D. employer
With academic jobs no longer the norm, universities adapt with career data and training.
- Rare diseases prompted care in ancient times
People with dwarfism and cleft palate may have been revered, bones suggest.
Feature
- Flashes in the scan
A homespun telescope in western Canada could solve the mystery of fast radio bursts by detecting dozens each day.
- Nowhere to hide
The most poached and trafficked of all animals, pangolins could vanish before scientists really get to know them.
Working Life
Letters
Books et al.
- What lies beneath
An idiosyncratic biography of bone probes the secrets and sensitive spots of the human skeletal system
- Marketing “healthy” babies
Does the rhetoric of consumer genetics aim to eliminate disability without mentioning it?
Policy Forum
- The crisis of democracy and the science of deliberation
Citizens can avoid polarization and make sound decisions
Perspectives
- Improving surface-wetting characterization
Awareness of instrument inaccuracies will boost the development of liquid-repellent coatings
- Histone modifiers are oxygen sensors
Hypoxia signals directly to chromatin via histone demethylases to alter gene expression
- Tissue-specificity in cancer: The rule, not the exception
Cancer driver genes exhibit remarkable tissue-specificity
- A master regulator of regeneration
Study of panther worm reveals a pioneer transcription factor that regulates regeneration
- Toward a clearer view into human prehistory
An ancient DNA study highlights ancient population patterns on the Iberian Peninsula
- Mapping the lung
Macrophages are redefined on the basis of gene expression, tissue localization, and function
Research Articles
- Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Independent populations of tissue-resident macrophages occupy distinct niches within their tissues of residence.
- Human sound systems are shaped by post-Neolithic changes in bite configuration
Diet-induced changes in the human bite over recent millennia led to the spread of new speech sounds, including “f” and “v.”
- Acoel genome reveals the regulatory landscape of whole-body regeneration
The genome of the acoel worm Hofstenia miamia elucidates a gene regulatory network that underlies the ability to regenerate.
- The oceanic sink for anthropogenic CO2 from 1994 to 2007
Ocean uptake of atmospheric CO2 continued apace between 1994 and 2007.
Reports
- Redefining near-unity luminescence in quantum dots with photothermal threshold quantum yield
CdSe/CdS nanoparticles have been synthesized with external luminescence efficiencies that exceed 99.5%.
- Terminal coordination of diatomic boron monofluoride to iron
A boron fluoride ligand isoelectronic with carbon monoxide binds to iron in similar but stronger fashion.
- A molecular perovskite solid solution with piezoelectricity stronger than lead zirconate titanate
A molecular ferroelectric perovskite solid solution has piezoelectric properties similar to those of ceramics.
- Males as somatic investment in a parthenogenetic nematode
The parthenogenetic nematode Mesorhabditis belari requires male sperm to activate its eggs but, for the most part, does not use it.
- Herbivores as drivers of negative density dependence in tropical forest saplings
Damage to saplings by herbivores rather than resource competition maintains local tree diversity in tropical rainforests.
- Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Certain chromatin regulators can directly sense changes in oxygen levels, leading to changes in gene expression.
- Hypoxia induces rapid changes to histone methylation and reprograms chromatin
Certain chromatin regulators can directly sense changes in oxygen levels, leading to changes in gene expression.
- RIT1 oncoproteins escape LZTR1-mediated proteolysis
Mutations that protect a small guanosine triphosphatase from its normal proteolytic degradation lead to excessive growth factor signaling.
- The genomic history of the Iberian Peninsula over the past 8000 years
Analyses of ancient human genomes document 7000 years of genetic changes in the Iberian Peninsula.
About The Cover
COVER A young cancer patient gazes out a window, perhaps wondering what the future holds. For many children with cancer, the future is bright. Thanks to treatment advances, the average cure rate in high-income countries now exceeds 80%. Collaborative research may yield new treatments with fewer side effects and help improve cure rates in lower-income countries. See page 1164.
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