Circadian Rhythm

Circadian muscle mastery

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Science  15 Mar 2019:
Vol. 363, Issue 6432, pp. 1188-1189
DOI: 10.1126/science.363.6432.1188-c

Circadian rhythms exist in almost all mammalian cells. The molecular clock is composed of transcriptional and translational components that show oscillatory behavior and are entrained by external cues, such as mealtimes, and thus keep time and regulate gene expression downstream. Core molecular-clock components can also be expressed in a tissue-specific way. For instance, the transcription factor MYOD1 serves as the muscle master gene regulator. It mediates gene-expression responses to external cues, such as nutrient surges after mealtimes. Hodge et al. observed that MYOD1 can also bind to an enhancer within the clock gene Bmal1 to regulate its expression. In turn, BMAL1 protein interacts with molecularclock components to increase muscle-specific gene expression in a daily cyclical manner. Hence, MYOD1 also acts as a “clock amplifier” in muscle to increase gene expression at particular times during the diurnal cycle.

eLife 8, e43017 (2019).

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