Research Article

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

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Science  15 Mar 2019:
Vol. 363, Issue 6432, eaau0964
DOI: 10.1126/science.aau0964

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Tissue macrophages have a split personality

Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues.

Science, this issue p. eaau0964; see also p. 1154