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Editorial Expression of Concern

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Science  29 Mar 2019:
Vol. 363, Issue 6434, pp. 1406
DOI: 10.1126/science.aax2933

On 14 October 2016, Science published the Research Article “Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy” by S. N. Byrareddy et al. (1). We have learned that the virus used in this study was a form of SIV with a stop codon in the SIV Nef gene. While this defect is apparently corrected over time in vivo, the use of this virus variant could affect the results presented in this Research Article. Science is publishing this Editorial Expression of Concern to alert readers while we await further information that will allow us to determine whether further action is required.

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