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Science  29 Mar 2019:
Vol. 363, Issue 6434, pp. 1468
DOI: 10.1126/science.363.6434.1468

Flow-Chemistry Platform

The fReactor from Asynt is an affordable device created to bring the many advantages of flow chemistry to your laboratory through easy-to-use, flexible, and intuitive design. The platform consists of five modules that combine to give a reaction zone delivering a good residence time distribution. These interconnected modules are located on a metal heat-transfer baseplate that sits on a conventional laboratory hotplate stirrer. Integrating the efficiency of pipe-flow processing with the advanced mixing of a continuous stirred-tank reactor, fReactor provides chemists with a versatile "plug-and-play" setup allowing a wide range of continuous-flow processing, with little expertise required.

X-Ray Microscopes

The ZEISS Xradia 610 and 620 Versa X-ray microscopes excel at delivering fast, nondestructive imaging of intact samples without sacrificing resolution and contrast, over the full range of power and kV. The two biggest challenges in X-ray computed tomography are maintaining resolution on large sample sizes at long working distances, while simultaneously maximizing resolution and X-ray flux for greater throughput. Both instruments address these challenges, providing a high-power X-ray source for significantly higher X-ray flux. This leads to faster tomography scans and up to twofold-higher throughput—without compromising spatial resolution. ZEISS X-ray microscopes are designed to be upgradeable and extendable with future innovations and developments, to protect our customers' investment.

Ultrasensitive Online Viscometer

Testa Analytical Solutions introduces a highly sensitive, online differential viscometer that can be used as part of a triple detector gel permeation chromatography/size-exclusion chromatography (GPC/SEC) system to determine the size and conformation of all types of synthetic polymers, biopolymers, proteins, and peptides. The detector incorporates technological innovations that dramatically reduce the noise level and increase sensitivity by more than an order of magnitude as compared to any viscometer currently available. This significant advance allows usage at much lower flow rates than before. Consequently, detection of lower molecular weights and at lower concentration is now routinely possible. Semi-micro GPC/SEC chromatography applications will benefit from this new detector.

Freeze Dryers

LyoConstellation from SP Scientific is a freeze-drying system with powerful refrigeration, delivering expanded equipment capability and a large process space. It can address early-stage development under aseptic and controlled conditions, behaving in the same manner once it is ready for scale-up and commercialization. The LyoConstellation series—including the S10, S20, and S30, and offering shelf capacities from 9.8 ft2 (1 m2) to 33 ft2 (3 m2)—are all equipped as standard to provide high capacity, broaden equipment capability, and expand design space. Configurable with the latest technologies, including SMART cycle optimization technology, ControLyo ice nucleation technology, and LyoFlux TDLAS (tunable diode laser absorption spectroscopy) for vapor mass flow measurement and inference of critical data such as batch product temperature and batch Kv (vial heat transfer coefficient), LyoConstellation brings you an unmatched array of process analytical data.

Experimental Cell Lines

AMS Biotechnology (AMSBIO) experimental cell lines give you the power to screen antibodies and ligands against your target, enhancing your search for new CAR T therapies. A therapeutic chimeric antigen receptor (CAR) is a transmembrane protein designed with an extracellular domain based on an antibody single-chain variable fragment (scFv) and intracellular signaling domains derived from the T-cell receptor gamma chain, along with other costimulatory receptors. The scFv provides a specific binding domain that recognizes target proteins on cancer cells. A patient's own T cells are isolated and activated, then transfected with a gene expressing the CAR. This reprograms the T cells to identify and attack tumor cells expressing the target protein, creating personalized immune cells created to specifically target the patient's cancer. Stable CHO recombinant cell lines are available from AMSBIO for constitutively expressing full-length human CD123, PSMA, and ICOSL.

CRISPR Screening Service

Horizon has extended its CRISPR Screening Service to include ex vivo T lymphocytes. The extension meets the requirements of immunology-based research in drug discovery, enabling new gene targets to be identified in biologically and potentially therapeutically relevant settings. CRISPR screens in primary T lymphocytes have proved challenging, owing to complex issues around the introduction of the screening components and Cas9 in particular. Horizon has adapted its established CRISPRko (knockout) platform to address these issues and to deliver a robust screening platform in human T lymphocytes, which will enable investigation of complex biological processes and novel targets. Horizon has added CRISPRko screens in ex vivo T lymphocytes to its established CRISPR screening formats—CRISPRko, CRISPRi (interference), and CRISPRa (activation)—in cancer cell lines.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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