Research Article

Structure and dynamics of the active human parathyroid hormone receptor-1

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Science  12 Apr 2019:
Vol. 364, Issue 6436, pp. 148-153
DOI: 10.1126/science.aav7942

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Bone-cell regulation, fleshed out

One of many medically relevant G protein–coupled receptors, parathyroid hormone receptor-1 (PTH1R) functions in the control of calcium homeostasis and bone physiology. Zhao et al. used cryo–election microscopy to observe the structure of PTH1R in a complex with a modified form of parathyroid hormone and stimulatory G protein. The structural model helps explain how parathyroid hormone interacts with its receptor and the molecular basis for receptor activation.

Science, this issue p. 148