Research Article

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

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Science  12 Apr 2019:
Vol. 364, Issue 6436, eaat8078
DOI: 10.1126/science.aat8078

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  • RE: Ketamine Ultimately Increases Testosterone via Testosterone Rebound

    I suggest the findings of Moda-Sava, et al., and positive effects of ketamine regarding depression, result from rebound increases in testosterone. Ketamine reduces testosterone. I suggest this eventually triggers a "testosterone rebound" which ultimately increases testosterone. Testosterone is known to increase dendritic spines.

    Competing Interests: None declared.