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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

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Science  19 Apr 2019:
Vol. 364, Issue 6437, pp. 289-292
DOI: 10.1126/science.aav9973

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vol. 364 no. 6437 289-292

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History: 
  • Received for publication November 8, 2018
  • Accepted for publication February 17, 2019
  • .

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  1. Erwei Zuo1,2,*,
  2. Yidi Sun3,*,
  3. Wu Wei4,5,6,*,
  4. Tanglong Yuan2,*,
  5. Wenqin Ying1,
  6. Hao Sun7,
  7. Liyun Yuan4,
  8. Lars M. Steinmetz5,8,9,,
  9. Yixue Li4,10,11,,
  10. Hui Yang1,
  1. 1Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  2. 2Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
  3. 3CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
  4. 4Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  5. 5Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.
  6. 6Center for Biomedical Informatics, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai 200040, China.
  7. 7University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0726, USA.
  8. 8Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA.
  9. 9Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
  10. 10Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200438, China.
  11. 11Shanghai Center for Bioinformation Technology, Shanghai Industrial Technology Institute, Shanghai 201203, China.
  1. Corresponding author. Email: lars.steinmetz{at}stanford.edu (L.M.S.); yxli{at}sibs.ac.cn (Y.L.); huiyang{at}ion.ac.cn (H.Y.)
  1. * These authors contributed equally to this work.

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