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Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

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Science  19 Apr 2019:
Vol. 364, Issue 6437, pp. 292-295
DOI: 10.1126/science.aaw7166

Article Information

vol. 364 no. 6437 292-295

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History: 
  • Received for publication January 20, 2019
  • Accepted for publication February 17, 2019

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  1. Shuai Jin1,2,*,
  2. Yuan Zong1,2,*,
  3. Qiang Gao3,*,
  4. Zixu Zhu1,2,
  5. Yanpeng Wang1,
  6. Peng Qin4,
  7. Chengzhi Liang2,3,
  8. Daowen Wang1,2,
  9. Jin-Long Qiu5,
  10. Feng Zhang6,
  11. Caixia Gao1,2,
  1. 1State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  2. 2University of Chinese Academy of Sciences, Beijing 100864, China.
  3. 3State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
  4. 4Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China.
  5. 5State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  6. 6Department of Plant and Microbial Biology, Center for Plant Precision Genomics, The Microbial and Plant Genomics Institute, University of Minnesota, Minneapolis, MN 55108, USA.
  1. Corresponding author. E-mail: cxgao{at}genetics.ac.cn
  1. * These authors contributed equally to this work.

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Apr 2019792222691081
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