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The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

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Science  26 Apr 2019:
Vol. 364, Issue 6438, pp. 389-394
DOI: 10.1126/science.aav0778

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The architecture of a signaling hub

Adenylyl cyclases (ACs) respond to a variety of inputs to generate the signaling molecule cyclic adenosine monophosphate. ACs are regulated by G proteins, which are activated by upstream receptors. Qi et al. determined the structure of bovine membrane AC9 bound to an activated G protein αs subunit by cryo–electron microscopy at 3.4-angstrom resolution. The structure provides the full architecture of AC9, including a helical domain that connects the transmembrane and catalytic domains. The model reveals how the domains interact to regulate enzymatic activity, including suggesting a mechanism of self-inhibition.

Science, this issue p. 389