Adult-born neurons in brain circuitry

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Science  10 May 2019:
Vol. 364, Issue 6440, pp. 530
DOI: 10.1126/science.aax5186

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The mammalian hippocampus is often referred to as the gateway to memory formation. By receiving information from numerous other brain regions, this structure has a privileged position not only in learning and memory processes but also in regulating emotional behaviors. On page 578 of this issue, Luna et al. (1) provide details on how the entorhinal cortex—the main hippocampal afferent that conducts sensory information into the hippocampal circuitry—differentially modulates the activity of local circuits in the dentate gyrus, the first relay station within the hippocampal circuit.