Research Article

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

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Science  10 May 2019:
Vol. 364, Issue 6440, pp. 552-557
DOI: 10.1126/science.aaw5188

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G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs. For example, five subtypes of muscarinic acetylcholine receptors (M1R to M5R) play different roles in the nervous system by binding to different G proteins. Maeda et al. determined cryo–electron microscopy structures of M1R and M2R bound to their respective G proteins. A side-by-side comparison provided a molecular understanding of G protein–coupling selectivity.

Science, this issue p. 552

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