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Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies

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Science  10 May 2019:
Vol. 364, Issue 6440, pp. 593-597
DOI: 10.1126/science.aau8287

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Cooperativity in synthetic gene circuits

Synthetic biologists would like to be able to make gene regulatory circuits that mimic key properties of eukaryotic gene regulation. Taking a cue from multimeric transcription factor complexes, Bashor et al. developed synthetic transcriptional circuits that produce nonlinear behavior from cooperativity (see the Perspective by Ng and El-Samad). Their system uses clamp proteins with multiple protein-interaction domains. Circuit behavior can be tuned by altering the number or affinities of the interactions according to a mathematical model. The authors created synthetic circuits with desired functions common in biology, for example, switch-like behavior or Boolean decision functions.

Science, this issue p. 593; see also p. 531

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