Research Article

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

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Science  24 May 2019:
Vol. 364, Issue 6442, eaaw4295
DOI: 10.1126/science.aaw4295

Article Information

vol. 364 no. 6442

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History: 
  • Received for publication December 19, 2018
  • Accepted for publication April 5, 2019
  • .

Author Information

  1. Emma K. Persson1,2,*,
  2. Kenneth Verstraete3,4,*,
  3. Ines Heyndrickx1,2,*,
  4. Elien Gevaert5,
  5. Helena Aegerter1,2,
  6. Jean-Michel Percier6,
  7. Kim Deswarte1,2,
  8. Koen H. G. Verschueren3,4,
  9. Ann Dansercoer3,4,
  10. Delphine Gras7,
  11. Pascal Chanez7,8,
  12. Claus Bachert5,9,
  13. Amanda Gonçalves10,11,
  14. Hanne Van Gorp1,2,
  15. Hans De Haard6,
  16. Christophe Blanchetot6,
  17. Michael Saunders6,
  18. Hamida Hammad1,2,
  19. Savvas N. Savvides3,4,,
  20. Bart N. Lambrecht1,2,12,
  1. 1Immunoregulation Unit, VIB Center for Inflammation Research, Ghent, Belgium.
  2. 2Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  3. 3Unit for Structural Biology, VIB Center for Inflammation Research, Ghent, Belgium.
  4. 4Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.
  5. 5Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium.
  6. 6arGEN-X, Ghent, Belgium.
  7. 7Aix Marseille University, INSERM, INRA, C2VN, Marseille, France.
  8. 8Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-HM, Marseille, France.
  9. 9Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden.
  10. 10BioImaging Core, VIB Inflammation Research Center, Ghent, Belgium.
  11. 11Department of Biomedical Molecular Biology, Ghent University, Belgium.
  12. 12Department of Pulmonary Medicine, ErasmusMC, Rotterdam, Netherlands.
  1. Corresponding author. Email: bart.lambrecht{at}ugent.be (B.N.L.); savvas.savvides{at}ugent.be (S.N.S.)
  1. * These authors contributed equally to this work.

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