Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso

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Science  31 May 2019:
Vol. 364, Issue 6443, pp. 894-897
DOI: 10.1126/science.aaw8737

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Targeting mosquitoes to target malaria

Anopheline mosquitoes transmit the malaria parasite, but the insects themselves are prone to their own infections. Lovett et al. engineered a specific fungal pathogen of anophelines to carry insect-selective toxins. The effectiveness of this fungus for controlling mosquitoes was trialed in near-field conditions in Burkina Faso in a setup called MosquitoSphere. Approximately 75% of wild insecticide-resistant mosquitoes released into the environment became infected with the transgenic fungus, causing population collapse within 45 days.

Science, this issue p. 894