Research Article

Spatiotemporal structure of cell fate decisions in murine neural crest

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Science  07 Jun 2019:
Vol. 364, Issue 6444, eaas9536
DOI: 10.1126/science.aas9536

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Binary decisions refine fate decisions

Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov et al. analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other.

Science, this issue p. eaas9536; see also p. 937