Research Article

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

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Science  07 Jun 2019:
Vol. 364, Issue 6444, eaaw0726
DOI: 10.1126/science.aaw0726

Article Information

vol. 364 no. 6444

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History: 
  • Received for publication November 15, 2018
  • Accepted for publication May 2, 2019
  • .

Author Information

  1. Keren Yizhak1,
  2. François Aguet1,
  3. Jaegil Kim1,
  4. Julian M. Hess1,
  5. Kirsten Kübler1,2,3,
  6. Jonna Grimsby1,
  7. Ruslana Frazer1,
  8. Hailei Zhang1,
  9. Nicholas J. Haradhvala1,2,
  10. Daniel Rosebrock1,
  11. Dimitri Livitz1,
  12. Xiao Li1,
  13. Eila Arich-Landkof1,2,
  14. Noam Shoresh1,
  15. Chip Stewart1,
  16. Ayellet V. Segrè1,3,4,
  17. Philip A. Branton5,
  18. Paz Polak6,
  19. Kristin G. Ardlie1,
  20. Gad Getz1,2,3,7,*
  1. 1Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  2. 2Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  3. 3Harvard Medical School, Boston, MA, USA.
  4. 4Ocular Genomics Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA.
  5. 5Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute, Bethesda, MD, USA.
  6. 6Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
  7. 7Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  1. *Corresponding author. Email: gadgetz{at}broadinstitute.org

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