PerspectiveNeuroscience

Targeting microglia in brain disorders

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Science  05 Jul 2019:
Vol. 365, Issue 6448, pp. 32-33
DOI: 10.1126/science.aau9100

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Summary

When the neuroscientist Pío del Río Hortega first characterized “microglia” in 1919 using silver carbonate staining of animal and human brain tissues, he was impressed by the morphological plasticity and capacity to phagocytose (ingest) of the resident immune effector cells, called microglia (1). A century later, technological advances in molecular biology, imaging, and single-cell analysis have provided fascinating insights into the dynamic changes of microglia in response to aging and brain diseases, revealing their potential as therapeutic targets.

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