Technical Comments

Comment on “Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality”

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Science  12 Jul 2019:
Vol. 365, Issue 6449, eaax5552
DOI: 10.1126/science.aax5552


Mina et al. (Reports, 8 May 2015, p. 694) used population-level statistical analysis to argue that measles infection results in a 2- to 3-year immunomodulation, implicating measles in substantially more child mortality than previously thought. We show, using both simulation and data from Iceland, that the statistical approach used may be confounded by the 2-year periodicity of measles incidence in the areas studied.

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