Technical Comments

Response to Comment on “Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality”

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Science  12 Jul 2019:
Vol. 365, Issue 6449, eaax6498
DOI: 10.1126/science.aax6498

Abstract

Thakkar and McCarthy suggest that periodicity in measles incidence artifactually drives our estimates of a 2- to 3-year duration of measles “immune-amnesia.” We show that periodicity has a negligible effect relative to the immunological signal we detect, and demonstrate that immune-amnesia is largely undetectable in small populations with large fluctuations in mortality of the type they use for illustration.

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