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Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

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Science  19 Jul 2019:
Vol. 365, Issue 6450, eaav9518
DOI: 10.1126/science.aav9518

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vol. 365 no. 6450

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History: 
  • Received for publication November 7, 2018
  • Resubmitted April 10, 2019
  • Accepted for publication June 4, 2019
  • .

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Author Information

  1. Ross Nortley1,
  2. Nils Korte1,*,
  3. Pablo Izquierdo1,*,
  4. Chanawee Hirunpattarasilp1,*,
  5. Anusha Mishra2,*,
  6. Zane Jaunmuktane3,4,*,
  7. Vasiliki Kyrargyri1,*,,
  8. Thomas Pfeiffer1,
  9. Lila Khennouf1,
  10. Christian Madry1,,
  11. Hui Gong1,
  12. Angela Richard-Loendt3,
  13. Wenhui Huang5,
  14. Takashi Saito6,
  15. Takaomi C. Saido6,
  16. Sebastian Brandner3,7,
  17. Huma Sethi8,
  18. David Attwell1,§
  1. 1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  2. 2Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.
  3. 3Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
  4. 4Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  5. 5Molecular Physiology, CIPMM, University of Saarland, D-66421 Homburg, Germany.
  6. 6Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.
  7. 7Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  8. 8Division of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  1. §Corresponding author. Email: d.attwell{at}ucl.ac.uk
  1. * These authors contributed equally to this work.

  • Present address: Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, 115 21 Athens, Greece.

  • Present address: Institute of Neurophysiology, Charité-Universitätsmedizin, 10117 Berlin, Germany.

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