Research Article
Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes
- View ORCID ProfileRoss Nortley1,
- View ORCID ProfileNils Korte1,*,
- View ORCID ProfilePablo Izquierdo1,*,
- View ORCID ProfileChanawee Hirunpattarasilp1,*,
- View ORCID ProfileAnusha Mishra2,*,
- View ORCID ProfileZane Jaunmuktane3,4,*,
- Vasiliki Kyrargyri1,*,†,
- View ORCID ProfileThomas Pfeiffer1,
- View ORCID ProfileLila Khennouf1,
- View ORCID ProfileChristian Madry1,‡,
- View ORCID ProfileHui Gong1,
- View ORCID ProfileAngela Richard-Loendt3,
- View ORCID ProfileWenhui Huang5,
- View ORCID ProfileTakashi Saito6,
- View ORCID ProfileTakaomi C. Saido6,
- View ORCID ProfileSebastian Brandner3,7,
- Huma Sethi8,
- View ORCID ProfileDavid Attwell1,§
- 1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
- 2Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.
- 3Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
- 4Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
- 5Molecular Physiology, CIPMM, University of Saarland, D-66421 Homburg, Germany.
- 6Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.
- 7Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
- 8Division of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
- ↵§Corresponding author. Email: d.attwell{at}ucl.ac.uk
↵* These authors contributed equally to this work.
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Science 19 Jul 2019:
Vol. 365, Issue 6450, eaav9518
DOI: 10.1126/science.aav9518
Vol. 365, Issue 6450, eaav9518
DOI: 10.1126/science.aav9518
Ross Nortley
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Nils Korte
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Pablo Izquierdo
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Chanawee Hirunpattarasilp
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Anusha Mishra
2Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Zane Jaunmuktane
3Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
4Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Vasiliki Kyrargyri
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Thomas Pfeiffer
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Lila Khennouf
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Christian Madry
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Hui Gong
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Angela Richard-Loendt
3Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Wenhui Huang
5Molecular Physiology, CIPMM, University of Saarland, D-66421 Homburg, Germany.
Takashi Saito
6Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.
Takaomi C. Saido
6Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.
Sebastian Brandner
3Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
7Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Huma Sethi
8Division of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
David Attwell
1Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
