PerspectiveImmunology

Immune control of the microbiota prevents obesity

See allHide authors and affiliations

Science  26 Jul 2019:
Vol. 365, Issue 6451, pp. 316-317
DOI: 10.1126/science.aay2057

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Obesity is a complex disease that is influenced by a mixture of genetic, behavioral, and environmental variables, such as the ability to metabolize nutrients, how much food is eaten, and diet composition. Adding to the complexity are the diverse communities of intestinal bacteria—known as the microbiota—that can influence whether obesity develops or not. But which species of gut bacteria predispose to obesity and which protect against it? And how do these bacteria become established in the gut? On page 340 of this issue, Petersen et al. (1) show that the immune system promotes gut colonization by bacteria that protect against obesity. The findings reveal how defective immune control of the microbiota can provoke metabolic disease.

View Full Text