Research Article

Somatic evolution and global expansion of an ancient transmissible cancer lineage

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Science  02 Aug 2019:
Vol. 365, Issue 6452, eaau9923
DOI: 10.1126/science.aau9923

Article Information

vol. 365 no. 6452

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Print ISSN: 
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History: 
  • Received for publication August 22, 2018
  • Accepted for publication June 20, 2019
  • .

Author Information

  1. Adrian Baez-Ortega1,
  2. Kevin Gori1,*,
  3. Andrea Strakova1,*,
  4. Janice L. Allen2,
  5. Karen M. Allum3,
  6. Leontine Bansse-Issa4,
  7. Thinlay N. Bhutia5,
  8. Jocelyn L. Bisson1,6,
  9. Cristóbal Briceño7,
  10. Artemio Castillo Domracheva8,
  11. Anne M. Corrigan9,
  12. Hugh R. Cran10,
  13. Jane T. Crawford11,
  14. Eric Davis12,
  15. Karina F. de Castro13,
  16. Andrigo B. de Nardi14,
  17. Anna P. de Vos15,
  18. Laura Delgadillo Keenan16,
  19. Edward M. Donelan2,
  20. Adela R. Espinoza Huerta17,
  21. Ibikunle A. Faramade18,
  22. Mohammed Fazil19,
  23. Eleni Fotopoulou20,
  24. Skye N. Fruean21,
  25. Fanny Gallardo-Arrieta22,
  26. Olga Glebova23,
  27. Pagona G. Gouletsou24,
  28. Rodrigo F. Häfelin Manrique25,
  29. Joaquim J. G. P. Henriques26,
  30. Rodrigo S. Horta27,
  31. Natalia Ignatenko28,
  32. Yaghouba Kane29,
  33. Cathy King3,
  34. Debbie Koenig3,
  35. Ada Krupa30,
  36. Steven J. Kruzeniski17,
  37. Young-Mi Kwon1,
  38. Marta Lanza-Perea9,
  39. Mihran Lazyan31,
  40. Adriana M. Lopez Quintana32,
  41. Thibault Losfelt33,
  42. Gabriele Marino34,
  43. Simón Martínez Castañeda35,
  44. Mayra F. Martínez-López36,37,
  45. Michael Meyer38,
  46. Edward J. Migneco39,
  47. Berna Nakanwagi40,
  48. Karter B. Neal41,
  49. Winifred Neunzig3,
  50. Máire Ní Leathlobhair1,
  51. Sally J. Nixon42,
  52. Antonio Ortega-Pacheco43,
  53. Francisco Pedraza-Ordoñez44,
  54. Maria C. Peleteiro45,
  55. Katherine Polak46,
  56. Ruth J. Pye47,
  57. John F. Reece48,
  58. Jose Rojas Gutierrez49,
  59. Haleema Sadia50,
  60. Sheila K. Schmeling51,
  61. Olga Shamanova52,
  62. Alan G. Sherlock47,
  63. Maximilian Stammnitz1,
  64. Audrey E. Steenland-Smit4,
  65. Alla Svitich53,
  66. Lester J. Tapia Martínez17,
  67. Ismail Thoya Ngoka54,
  68. Cristian G. Torres55,
  69. Elizabeth M. Tudor56,
  70. Mirjam G. van der Wel57,
  71. Bogdan A. Viţălaru58,
  72. Sevil A. Vural59,
  73. Oliver Walkinton47,
  74. Jinhong Wang1,
  75. Alvaro S. Wehrle-Martinez60,
  76. Sophie A. E. Widdowson61,
  77. Michael R. Stratton62,
  78. Ludmil B. Alexandrov63,
  79. Iñigo Martincorena62,
  80. Elizabeth P. Murchison1,
  1. 1Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
  2. 2Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
  3. 3World Vets, Gig Harbor, USA.
  4. 4Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
  5. 5Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India.
  6. 6Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin EH25 9RG, UK.
  7. 7ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.
  8. 8Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.
  9. 9St. George's University, True Blue, Grenada.
  10. 10The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
  11. 11Animal Medical Centre, Belize City, Belize.
  12. 12International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, CA, USA.
  13. 13Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.
  14. 14Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), São Paulo, Brazil.
  15. 15Ladybrand Animal Clinic, Ladybrand, South Africa.
  16. 16Veterinary Clinic Sr. Dog’s, Guadalajara, Mexico.
  17. 17World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
  18. 18National Veterinary Research Institute, Vom, Nigeria.
  19. 19Animal Clinic, Mombasa, Kenya.
  20. 20Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.
  21. 21Animal Protection Society of Samoa, Apia, Samoa.
  22. 22Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
  23. 23Veterinary Clinic BIOCONTROL, Moscow, Russia.
  24. 24Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.
  25. 25Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.
  26. 26OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.
  27. 27Universidade Vila Velha, Vila Velha, Brazil.
  28. 28Veterinary Clinic Zoovetservis, Kiev, Ukraine.
  29. 29École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.
  30. 30Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  31. 31Vetexpert Veterinary Group, Yerevan, Armenia.
  32. 32Veterinary Clinic Lopez Quintana, Maldonado, Uruguay.
  33. 33Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.
  34. 34Department of Veterinary Sciences, University of Messina, Messina, Italy.
  35. 35Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.
  36. 36School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.
  37. 37Cancer Development and Innate Immune Evasion Lab, Champalimaud Center for the Unknown, Lisbon, Portugal.
  38. 38Touray & Meyer Vet Clinic, Serrekunda, The Gambia.
  39. 39Hillside Animal Hospital, St. Louis, MO, USA.
  40. 40The Kampala Veterinary Surgery, Kampala, Uganda.
  41. 41Asavet Veterinary Charities, Tucson, AZ, USA.
  42. 42Vets Beyond Borders, Bylakuppe, India.
  43. 43Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.
  44. 44Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.
  45. 45Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.
  46. 46Four Paws International, Vienna, Austria.
  47. 47Vets Beyond Borders, The Rocks, Australia.
  48. 48Help in Suffering, Jaipur, India.
  49. 49Veterinary Clinic Dr José Rojas, Los Andes, Chile.
  50. 50Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.
  51. 51Corozal Veterinary Clinic, Corozal Town, Belize.
  52. 52Veterinary Clinic Vetmaster, Ramenskoye, Russia.
  53. 53State Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine.
  54. 54Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
  55. 55Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile
  56. 56Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.
  57. 57Animal Anti Cruelty League, Port Elizabeth, South Africa.
  58. 58Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.
  59. 59Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.
  60. 60Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.
  61. 61Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.
  62. 62Wellcome Sanger Institute, Hinxton, UK.
  63. 63Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
  1. Corresponding author. Email: epm27{at}cam.ac.uk
  1. * These authors contributed equally to this work.

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