Research Article

Laboratory mice born to wild mice have natural microbiota and model human immune responses

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Science  02 Aug 2019:
Vol. 365, Issue 6452, eaaw4361
DOI: 10.1126/science.aaw4361

Article Information

vol. 365 no. 6452

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History: 
  • Received for publication December 20, 2018
  • Resubmitted May 6, 2019
  • Accepted for publication June 27, 2019
  • .

Author Information

  1. Stephan P. Rosshart1,*,,
  2. Jasmin Herz2,,
  3. Brian G. Vassallo1,,§,
  4. Ashli Hunter1,
  5. Morgan K. Wall2,
  6. Jonathan H. Badger3,
  7. John A. McCulloch3,
  8. Dimitrios G. Anastasakis5,
  9. Aishe A. Sarshad5,||,
  10. Irina Leonardi7,
  11. Nicholas Collins4,
  12. Joshua A. Blatter8,
  13. Seong-Ji Han4,
  14. Samira Tamoutounour4,
  15. Svetlana Potapova10,
  16. Mark B. Foster St. Claire10,
  17. Wuxing Yuan3,9,
  18. Shurjo K. Sen3,9,
  19. Matthew S. Dreier1,
  20. Benedikt Hild1,
  21. Markus Hafner5,
  22. David Wang6,
  23. Iliyan D. Iliev7,
  24. Yasmine Belkaid4,
  25. Giorgio Trinchieri3,
  26. Barbara Rehermann1,*
  1. 1Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA.
  2. 2Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  3. 3Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA.
  4. 4Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  5. 5Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease, Bethesda, MD 20892, USA.
  6. 6Departments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  7. 7The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA.
  8. 8Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  9. 9Leidos Biomedical Research, Inc., Microbiome and Genetics Core, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  10. 10Laboratory of Animal Sciences Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA.
  1. *Corresponding author. Email: stephan.rosshart{at}uniklinik-freiburg.de (S.P.R.); rehermann{at}nih.gov (B.R.)
  1. These authors contributed equally to this work.

  • Present address: Universitätsklinikum Freiburg, Klinik für Innere Medizin II, University of Freiburg, 79106 Freiburg, Germany.

  • § Present address: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Ave., 68-132, Cambridge, MA 02139.

  • || Present address: Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden.

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