Specialized cutaneous Schwann cells initiate pain sensation

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Science  16 Aug 2019:
Vol. 365, Issue 6454, pp. 695-699
DOI: 10.1126/science.aax6452

A newly discovered cell type for pain perception

Pain has been thought to be initiated by activation of free nerve endings without end organs in the skin. In contrast to this paradigm, Abdo et al. discovered a previously unknown meshlike organ covering the skin that senses dangerous environmental stimuli (see the Perspective by Doan and Monk). This organ is built from specialized glial cells located in the epidermal-dermal border and is sufficient and required for initiation of mechanical pain transduction.

Science, this issue p. 695; see also p. 641

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