Aging

Microbiota and age-related disease

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Science  06 Sep 2019:
Vol. 365, Issue 6457, pp. 996
DOI: 10.1126/science.365.6457.996-a

The microbiota in the mouse gut becomes disrupted in premature aging disease (progeria).

PHOTO: DAVID M. PHILLIPS/SCIENCE SOURCE

Gut bacteria have been shown to influence numerous conditions including cancer, diabetes, and neurological diseases. Bárcena et al. explored how the microbiota affects aging by analyzing the gut microbiota of children with the premature aging disorder called progeria. Patients with accelerated aging displayed greater disturbances in their intestinal bacteria during disease progression when compared with normally aging individuals. Using mouse models of aging, the researchers found that transplantation of fecal microbiota from healthy mice extended the life span of two different models of progeria. This effect correlated with the restoration of levels of secondary bile acids.

Nat. Med. 25, 1234 (2019).

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