Contents
13 September 2019
Vol 365, Issue 6458
Vol 365, Issue 6458
Special Issue
Mountain Life
Introduction to special issue
News
- Fire on the mountain
More than 2 centuries after Humboldt charted life zones on Ecuador's Chimborazo, climate change is transforming the peak.
- Hypoxia city
In a remote Andean mining town, scientists are studying how life at extremely low oxygen levels ravages the body.
- Sunken summits
Earth's seamounts hold biological and mineral riches. Can deep-sea mining and conservation coexist?
Reviews
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Accusations fly over threat to rarest great ape
A new dam on Sumatra poses an existential risk to the Tapanuli orangutan, scientists say.
- CRISPR reveals some cancer drugs hit unexpected targets
Method that generated drug leads may be flawed.
- Robot detector to map cosmos for clues to dark energy's force
Upgraded Arizona telescope will survey 35 million galaxies.
- Open-access megajournals lose momentum
Concerns include declining volume, slower publication, and softening citation measures.
- Chinese ties don't faze European funders
But in the United States and Australia, worries about China are affecting collaborations.
- India spots fallen moon craft, fails to make radio contact
Glitches dogged nation's first attempt to land on the moon.
- Quantum Darwinism seen in diamond traps
Concept of survival of the fittest could explain how reality emerges from quantum haze.
Feature
- War of nerves
An emerging relationship between the nervous system and tumor growth suggests new therapies.
Working Life
Letters
Books et al.
- Evolving emotions
An eminent fear researcher argues for an about-face in how we conceive of emotions
- Tales of a globe-trotting naturalist
A vivid biography of Alexander von Humboldt enlightens, but lacks greater historical context
Policy Forum
- Accelerating the movement for mountain peoples and policies
Policies can have impacts extending far downstream
Perspectives
- Humboldt for the Anthropocene
Humboldt's fusion of science and humanism can address contemporary challenges
- An expanding controversy
An independently calibrated measurement fortifies the debate around Hubble's constant
- Mitochondria teach ribosome assembly
Ribosome assembly factors regulate structure formation to prevent misfolding
- Making perfectly controlled arrays of molecules at rest
Molecular collisions are probed with ultracold optical traps
- Emerging uses of DNA mechanical devices
DNA mechanotechnology has applications in biological research and materials science
- The evolution of antibiotic resistance
Clinically relevant evolution studies are needed to help fight the spread of antibiotic resistance
Research Articles
- A measurement of the Hubble constant from angular diameter distances to two gravitational lenses
The rate of expansion of the Universe is determined from observations of gravitational lensing systems.
- Synthesis of a copper-supported triplet nitrene complex pertinent to copper-catalyzed amination
A copper complex long implicated in C–N bond formation has been spectroscopically and crystallographically characterized.
- Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery
Mitochondrial ribosome maturation in trypanosomes involves numerous assembly factors and the formation of large assembly intermediates.
- Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
Structures of six intermediates show how phospholipids are translocated from the outer to the inner leaflet of a eukaryotic cell membrane.
Reports
- An optical tweezer array of ultracold molecules
CaF molecules were laser cooled and trapped in a one-dimensional array of optical tweezers.
- Shape regulation of high-index facet nanoparticles by dealloying
An alloying-dealloying reaction with metals such as bismuth produced tetrahexahedral transition-metal nanoparticles.
- Non-Hermitian topological light steering
Topologically protected light paths can be controlled through optical illumination.
- Time-resolved crystallography reveals allosteric communication aligned with molecular breathing
A molecular movie of catalysis reveals the basis for half-of-the-sites binding and activity in a dimeric enzyme.
- N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication
Macrophages inhibit viral replication by inactivating an RNA demethylase, which leads to reduced levels of the metabolite itaconate.
- A neonicotinoid insecticide reduces fueling and delays migration in songbirds
During migratory stopover of white-crowned sparrows, consumption of seeds treated with neonicotinoids reduced fattening and delayed departure.
- Behavioral and neural correlates of hide-and-seek in rats
Rats and humans playing hide-and-seek together provides a paradigm for understanding the neural bases of play behavior.
Technical Comments
About The Cover
COVER Runoff water rushes through the valley below El Altar, Ecuador's fifth-tallest volcano. The Ecuadorian Andes were the cradle of mountain science, pioneered by Alexander von Humboldt. Two centuries on, mountain research continues to build on Humboldt's foundations, with key relevance for human society in the era of rapid climate change. See page 1092.
Photo: Ryan Heffernan/Cavan Images
