Reproduction

Reorganization to initiate ovulation

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Science  20 Sep 2019:
Vol. 365, Issue 6459, pp. 1261
DOI: 10.1126/science.365.6459.1261-a

Scanning electron micrograph (false color) of an ovarian follicle

PHOTO: P. BAGAVANDOSS/SCIENCE SOURCE

In mammalian reproduction, oocyte development begins before birth. The germ cell is surrounded by granulosa cells of the primordial follicle. As luteinizing hormone from the pituitary gland triggers follicle ovulation, transcriptional changes enable cellular differentiation and, ultimately, oocyte release. Bianco et al. use the systems biology approach called FAIRE-seq to map regulatory elements before and after the ovulatory signal and identify the mechanisms controlling the mouse follicle. After hormone signaling, granulosa cells display modifications in distal regulatory elements. The orphan nuclear receptor, liver receptor homolog-1, is remodeled and reprogrammed in granulosa cells to direct global transcription during early ovulation for processes including cytoskeletal architecture and cell migration.

Cell Rep. 28, 2443 (2019).

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