Immunology

A haven for T cells

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Science  20 Sep 2019:
Vol. 365, Issue 6459, pp. 1261
DOI: 10.1126/science.365.6459.1261-b

Memory T cells (MTCs) help the host to respond quickly and effectively to subsequent challenges by the same pathogen. During times of nutritional stress, the host may have to balance productive immune responses with competing claims on limited resources. In mice subjected to dietary restriction, Collins et al. found that MTCs translocate to the bone marrow where they enter a quiescent, energy-conserving state accompanied by reduced mechanistic target of rapamycin signaling. Glucocorticoid hormones mediated accumulation of several cell types, not only other immune cells, but also adipocytes in bone marrow. Adipocytes were important for recruitment and survival of MTCs in this niche. This adaptive response ensures that immune responses can persist during periods of caloric restriction.

Cell 178, 1088 (2019).

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