Metabolism

Sensing diet

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Science  27 Sep 2019:
Vol. 365, Issue 6460, pp. 1415-1416
DOI: 10.1126/science.365.6460.1415-f

The hypothalamic region of the brain is associated with regulation of metabolism and feeding. In mice fed a high-fat diet, innate immune cells in the brain called microglia become activated and hypothalamic inflammation occurs prior to the onset of weight gain. Kim et al. report that high-fat diets induce expression of the uncoupling protein 2 (Ucp2) gene, as well as mitochondrial changes in the microglia. Ablation of the Ucp2 gene in microglia prevented these changes and protected mice from high-fat diet–induced obesity.

Cell. Metab. 10.1016/j.cmet.2019.08.010 (2019).

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