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Chromosome errors in human eggs shape natural fertility over reproductive life span

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Science  27 Sep 2019:
Vol. 365, Issue 6460, pp. 1466-1469
DOI: 10.1126/science.aav7321

Article Information

vol. 365 no. 6460 1466-1469

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History: 
  • Received for publication December 5, 2018
  • Accepted for publication September 4, 2019
  • .

Author Information

  1. Jennifer R. Gruhn1,*,
  2. Agata P. Zielinska2,*,
  3. Vallari Shukla1,*,
  4. Robert Blanshard3,4,*,
  5. Antonio Capalbo5,
  6. Danilo Cimadomo6,
  7. Dmitry Nikiforov7,8,
  8. Andrew Chi-Ho Chan1,
  9. Louise J. Newnham3,
  10. Ivan Vogel1,
  11. Catello Scarica9,
  12. Marta Krapchev10,
  13. Deborah Taylor11,
  14. Stine Gry Kristensen7,
  15. Junping Cheng7,
  16. Erik Ernst12,
  17. Anne-Mette Bay Bjørn12,
  18. Lotte Berdiin Colmorn13,
  19. Martyn Blayney14,
  20. Kay Elder14,
  21. Joanna Liss10,15,
  22. Geraldine Hartshorne11,
  23. Marie Louise Grøndahl16,
  24. Laura Rienzi6,
  25. Filippo Ubaldi6,
  26. Rajiv McCoy17,
  27. Krzysztof Lukaszuk10,18,19,
  28. Claus Yding Andersen7,
  29. Melina Schuh2,
  30. Eva R. Hoffmann1,
  1. 1DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  2. 2Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany.
  3. 3Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
  4. 4Illumina Inc., Fulbourn, UK.
  5. 5Igenomix, Marostica, Italy.
  6. 6G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
  7. 7Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  8. 8Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy.
  9. 9DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy.
  10. 10INVICTA Fertility and Reproductive Center, Gdańsk, Poland.
  11. 11Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK.
  12. 12Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark.
  13. 13The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark.
  14. 14Bourn Hall Clinic, Cambridge, UK.
  15. 15Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland.
  16. 16Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark.
  17. 17Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
  18. 18Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.
  19. 19Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland.
  1. Corresponding author. Email: eva{at}sund.ku.dk
  1. * These authors contributed equally to this work.

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Sep 201948091701841
Oct 201941131790974
Nov 20191746496292
Dec 201933016288

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