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Chromosome errors in human eggs shape natural fertility over reproductive life span

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Science  27 Sep 2019:
Vol. 365, Issue 6460, pp. 1466-1469
DOI: 10.1126/science.aav7321

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  • Fertility Rates Need First of All a Social Support
    • Andrea Cioffi, Doctor under training in Forensic Medicine, Sapienza University of Rome. Italy.
    • Other Contributors:
      • Fernanda Cioffi, Gynecologists, Fertilitas Day Surgery Reproductive Medicine. Salerno, Italy.

    Gruhn et al. (1) found that this distinct shape originates from chromosomal errors in human eggs, which result in genomic imbalance and pregnancy loss.
    Certainly, this shows that the female organism has natural mechanisms at its disposal that protect it from pregnancies at a riskier age: adolescence and advanced age.
    There is a bioethical aspect to this discovery, in fact, it is automatic to wonder whether medically assisted procreation techniques (MAP) in women over 40 should be used without proper evaluation. In fact, MAP techniques cannot improve the quality of gametes and, therefore, if used on women over 40 years, are related to a lower chance of success and a higher risk of complications (2,3).
    The desire to procreate is a legitimate right, but it is probably necessary for the scientific community to inform women correctly, facilitating the understanding of a fundamental concept: the MAP, while being an absolutely effective and useful method to achieve the purpose of procreation, is not able to reverse and
    cancel the natural path of female fertility, which, in the course of life, increases and then decreases relentlessly, until the cessation of the reproductive capacity.
    Properly informing women is a fundamental step, also considering the current tendency to postpone the experience of pregnancy especially by Western women who decide to have a child later and of course with many difficulties, as easily deduced from the decrease in births...

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    Competing Interests: None declared.