Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

Wenyan Han; Jun Li; Kenneth A. Pelkey; Saurabh Pandey; Xiumin Chen; Ya-Xian Wang; Kunwei Wu; Lihao Ge; Tianming Li; David Castellano; Chengyu Liu; Ling-Gang Wu; Ronald S. Petralia; Joseph W. Lynch; Chris J. McBain; Wei Lu

doi:10.1126/science.aax5719

Report

Shisa7 is a GABA_A receptor auxiliary subunit controlling benzodiazepine actions

View ORCID ProfileWenyan Han¹,
View ORCID ProfileJun Li¹,*,
View ORCID ProfileKenneth A. Pelkey²,*,
View ORCID ProfileSaurabh Pandey¹,
View ORCID ProfileXiumin Chen³,
Ya-Xian Wang⁴,
View ORCID ProfileKunwei Wu¹,
View ORCID ProfileLihao Ge⁵,
View ORCID ProfileTianming Li¹,
View ORCID ProfileDavid Castellano¹,
View ORCID ProfileChengyu Liu⁶,
Ling-Gang Wu⁵,
Ronald S. Petralia⁴,
View ORCID ProfileJoseph W. Lynch³,
View ORCID ProfileChris J. McBain²,
View ORCID ProfileWei Lu¹,†

¹Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
²Cellular and Synaptic Neuroscience Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
³Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
⁴Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.
⁵Synaptic Transmission Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
⁶Transgenetic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

↵†Corresponding author. Email: luw4{at}mail.nih.gov

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science 11 Oct 2019:
Vol. 366, Issue 6462, pp. 246-250
DOI: 10.1126/science.aax5719

Wenyan Han

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Wenyan Han

Jun Li

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jun Li

Kenneth A. Pelkey

2Cellular and Synaptic Neuroscience Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kenneth A. Pelkey

Saurabh Pandey

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Saurabh Pandey

Xiumin Chen

3Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xiumin Chen

Ya-Xian Wang

4Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kunwei Wu

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kunwei Wu

Lihao Ge

5Synaptic Transmission Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lihao Ge

Tianming Li

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tianming Li

David Castellano

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for David Castellano

Chengyu Liu

6Transgenetic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chengyu Liu

Ling-Gang Wu

5Synaptic Transmission Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ronald S. Petralia

4Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joseph W. Lynch

3Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joseph W. Lynch

Chris J. McBain

2Cellular and Synaptic Neuroscience Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chris J. McBain

Wei Lu

1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Wei Lu
For correspondence: luw4@mail.nih.gov

Article
Figures & Data
Info & Metrics
eLetters
PDF

Fine control of brain GABA_A receptors

GABA_A (γ-aminobutyric acid type A) receptors are ligand-gated anion channels that mediate fast inhibitory transmission in the mammalian brain. Han et al. investigated if a protein called SHISA7 was involved in regulating GABA_A receptor expression and function (see the Perspective by Rudolph and Moss). SHISA7 was found at GABA-releasing synapses, where it interacted with GABA_A receptors, controlled receptor concentration at the synapse, sped up receptor deactivation kinetics, and modulated some behavioral properties of benzodiazepines. SHISA7 thus affects surface expression, gating kinetics, and pharmacology of GABA_A receptors in the brain.

Science, this issue p. 246; see also p. 185

http://www.sciencemag.org/about/science-licenses-journal-article-reuse

This is an article distributed under the terms of the Science Journals Default License.

View Full Text

Shisa7 is a GABA_A receptor auxiliary subunit controlling benzodiazepine actions

Fine control of brain GABA_A receptors

Science

Article Tools