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Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

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Science  11 Oct 2019:
Vol. 366, Issue 6462, pp. 246-250
DOI: 10.1126/science.aax5719

Fine control of brain GABAA receptors

GABAA (γ-aminobutyric acid type A) receptors are ligand-gated anion channels that mediate fast inhibitory transmission in the mammalian brain. Han et al. investigated if a protein called SHISA7 was involved in regulating GABAA receptor expression and function (see the Perspective by Rudolph and Moss). SHISA7 was found at GABA-releasing synapses, where it interacted with GABAA receptors, controlled receptor concentration at the synapse, sped up receptor deactivation kinetics, and modulated some behavioral properties of benzodiazepines. SHISA7 thus affects surface expression, gating kinetics, and pharmacology of GABAA receptors in the brain.

Science, this issue p. 246; see also p. 185

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