Research Article

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

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Science  11 Oct 2019:
Vol. 366, Issue 6462, eaav5728
DOI: 10.1126/science.aav5728

Some naïve T cell fates are sealed

Tissue-resident memory T (TRM) cells constitute a subpopulation of memory cells that reside in tissues instead of recirculating. CD8+ epithelial TRM (eTRM) cells, which occupy the epithelium of sites like the skin, require transforming growth factor–β (TGF-β) for their development. Mani et al. found that αV integrin–expressing dendritic cells, which activate and present TGF-β, are key (see the Perspective by Farber). Surprisingly, this interplay did not occur in the skin or draining lymph nodes during T cell priming. Rather, resting naïve CD8+ T cells interacted with αV integrin–expressing migratory dendritic cells during immune homeostasis, reversibly preconditioning them to become eTRM cells upon activation. A potent cytokine is thus controlled in a context-dependent manner and preimmune T cell repertoires may be less uniform than previously presumed.

Science, this issue p. eaav5728; see also p. 188

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