Review

Axonal transport: Driving synaptic function

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Science  11 Oct 2019:
Vol. 366, Issue 6462, eaaw9997
DOI: 10.1126/science.aaw9997

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From trafficking to maintenance

Neurons are remarkably polarized in that proteins made in the cytosol often need to travel many tens or hundreds of cell body lengths along axons to their sites of action in the synapse. Axonal transport of these components is driven by molecular motors along axonal microtubules. Guedes-Dias and Holzbaur review the cell biology of axonal transport and highlight the roles this fundamental process plays in organismal health.

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