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Science  18 Oct 2019:
Vol. 366, Issue 6463, pp. 386
DOI: 10.1126/science.366.6463.386

Protein Analysis System

Fluidic Analytics' Fluidity One-W assesses on-target protein interactions in solution, even in crude biological backgrounds such as cell lysates or blood plasma. This capability can produce detailed analyses of proteins in near-native states and in natural environments—facilitating earlier, more accurate analysis of targets for faster decision-making. Fluidic Analytics has made this possible with its proprietary diffusional sizing technology, which is based on the well-understood relationship between size and diffusion rate, and yields absolute size measurements. The measurements provided by the Fluidity One-W confirm the identity of complexes, allowing scientists to control for off-target binding and false positive measurements, and delivering zero ambiguity for the utmost confidence in results. The instrument's unique abilities and high sensitivity enable researchers to study proteins that are traditionally problematic for other systems, including membrane proteins, multiprotein complexes, and intrinsically disordered proteins.

E. coli Host Cell Protein Kit

Gyros Protein Technologies offers a host cell protein (HCP) kit for automated impurity analysis of biotherapeutics expressed in Escherichia coli systems. The kit is optimized for use in Gyrolab systems and has been developed as part of a licensing and supply agreement with Cygnus Technologies (part of Maravai LifeSciences), incorporating their industry standard E. coli HCP antibodies and other reagents. The Gyrolab E. coli HCP Kit quantifies HCP impurities from E. coli expression systems used in the production of biotherapeutics, a critical step in ensuring the efficacy and safety of the drug molecule.

PD-L1 Antibody Panel

In order to give you the best chance of finding the optimal PD-L1 clone for your research assay, you can now get access to four key recombinant monoclonal PD-L1 antibody clones from Abcam (73-10, 28-8, SP142, and CAL10), as well as the anti-mouse recombinant rabbit monoclonal EPR20529 and the mouse monoclonal PDL1/2746. PD-L1 (also known as B7-H1, CD274) is a ligand that binds to PD-1 (programmed cell death-1), expressed on activated T cells, to evade antitumor responses. PD-L1 plays a role in inhibiting T-cell activation and proliferation and has emerged as an important target in cancer treatment. PD-L1 protein detection by immunohistochemistry (IHC) testing is widely used as a predictive biomarker assay for anti–PD-1/PD-L1 therapies. You can now access all four anti-human recombinant rabbit monoclonal antibody clones in our trial-size panel kit.

Protein Standards

Atlas Antibodies introduces prequantified QPrEST Protein Standards for absolute quantification of proteins in biological samples such as cell lysate and plasma, using LC/MS. QPrESTs consist of 50–150 amino acids identical to a part of the corresponding human protein. They are produced recombinantly in the presence of stable, isotope-labeled (i.e., heavy) amino acids. One advantage of QPrESTs over other available protein standards is that they are added to the sample early in the workflow, prior to proteolytic digestion. The shared amino acid sequence of the QPrEST and the endogenous protein enable the QPrEST to correct for variation introduced during sample digestion, thereby increasing quantification accuracy.

Custom Protein Service

OriGene offers comprehensive, high-quality recombinant custom protein services from different expression systems, in addition to the standard catalog items. Our proprietary protein expression/purification technology maximizes the purity and yield of target proteins in different systems. We offer a complete "start-to-finish" service from the complementary DNA (gene) cloning step to the protein purification step, and downstream modifications such as tag addition/removal, endotoxin testing/removal, conjugations, and any other services you may request. Choose OriGene as your reliable partner for protein-related research, and we can help you accelerate your discovery in a timely, cost-effective, and affordable manner.

HCP ELISA Detection Kits

AMS Biotechnology has launched a range of ELISA Host Cell Protein (HCP) detection kits that allow you to discover host cell protein impurities in your therapeutic at any phase of product development. The kits are based on a sandwich ELISA test and come in a convenient, 96-well plate format. Specific HCP detection kits are available for popular expression systems, including CHO, Escherichia coli, Pichia, HEK293, and Protein A. Each kit allows quantification of up to 24 samples. Our HCP detection kits offer 5–10 times more sensitivity, greater antibody coverage, and lower lot-to-lot variations as compared to alternative kits, resulting in a more consistent, reliable antibody supply and a reduction in biomanufacturing costs.

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