Research Article

Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

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Science  25 Oct 2019:
Vol. 366, Issue 6464, pp. 454-460
DOI: 10.1126/science.aax7526

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Close-up of human cerebellar development

Early on, cerebellar development shares similarities across humans, nonhuman primates, and even mice. But differences emerge while development progresses, as cellular and molecular analyses by Haldipur et al. now reveal. The rhombic lip persists longer during cerebellar development in humans than in either the mouse or the macaque and generates a pool of neuroprogenitor cells. Similarly, the ventricular zone of the human cerebellum goes a step further than that of the mouse in developing an additional proliferative layer with outer radial glia cells. Transcriptome analysis revealed detailed similarities and differences between progenitor cells of the developing human cerebellum and neocortex.

Science, this issue p. 454

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