Research Article

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

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Science  25 Oct 2019:
Vol. 366, Issue 6464, pp. 460-467
DOI: 10.1126/science.aau6391

Article Information

vol. 366 no. 6464 460-467

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History: 
  • Received for publication July 2, 2018
  • Resubmitted July 19, 2019
  • Accepted for publication October 3, 2019
  • .

Author Information

  1. Yan Lu1,2,*,
  2. Yuping Zheng1,*,
  3. Étienne Coyaud3,*,
  4. Chao Zhang4,5,*,
  5. Apiraam Selvabaskaran6,
  6. Yuyun Yu1,
  7. Zizhen Xu1,
  8. Xialian Weng1,
  9. Ji Shun Chen1,
  10. Ying Meng1,
  11. Neil Warner7,
  12. Xiawei Cheng8,
  13. Yangyang Liu9,
  14. Bingpeng Yao10,
  15. Hu Hu9,
  16. Zonping Xia11,
  17. Aleixo M. Muise7,
  18. Amira Klip12,
  19. John H. Brumell7,13,
  20. Stephen E. Girardin6,
  21. Songmin Ying10,
  22. Gregory D. Fairn2,,
  23. Brian Raught3,14,,
  24. Qiming Sun8,,
  25. Dante Neculai1,
  1. 1Department of Cell Biology, and Department of Pathology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  2. 2Keenan Research Centre for Biomedical Sciences, St. Michael’s Hospital, Toronto, ON, Canada.
  3. 3Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  4. 4Department of Anatomy, School of Medicine, Zhejiang University, China School of Medicine, Zhejiang University, Hangzhou 310058, China.
  5. 5Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
  6. 6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
  7. 7SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
  8. 8Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
  9. 9Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
  10. 10Department of Pharmacology and Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou 310009, China.
  11. 11Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
  12. 12Cell Biology Program, Research Institute, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning (PGCRL), Toronto, ON, Canada.
  13. 13Department of Molecular Genetics and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  14. 14Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  1. Corresponding author. Email: greg.fairn{at}unityhealth.to (G.D.F.); brian.raught{at}uhnresearch.ca (B.R.); qmsun{at}zju.edu.cn (Q.S.); dneculai{at}zju.edu.cn (D.N.)
  1. * These authors contributed equally to this work.

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