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Higher-fitness yeast genotypes are less robust to deleterious mutations

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Science  25 Oct 2019:
Vol. 366, Issue 6464, pp. 490-493
DOI: 10.1126/science.aay4199

Article Information

vol. 366 no. 6464 490-493

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History: 
  • Received for publication June 18, 2019
  • Accepted for publication September 11, 2019
  • .

Author Information

  1. Milo S. Johnson1,2,3,
  2. Alena Martsul4,
  3. Sergey Kryazhimskiy4,*,
  4. Michael M. Desai1,2,3,5,*
  1. 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  2. 2Quantitative Biology Initiative, Harvard University, Cambridge, MA 02138, USA.
  3. 3NSF-Simons Center for Mathematical and Statistical Analysis of Biology, Harvard University, Cambridge, MA 02138, USA.
  4. 4Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  5. 5Department of Physics, Harvard University, Cambridge, MA 02138, USA.
  1. *Corresponding author. Email: mdesai{at}oeb.harvard.edu (M.M.D.); skryazhi{at}ucsd.edu (S.K.)

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