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Higher-fitness yeast genotypes are less robust to deleterious mutations
- Milo S. Johnson1,2,3,
- Alena Martsul4,
- Sergey Kryazhimskiy4,*,
- Michael M. Desai1,2,3,5,*
- 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
- 2Quantitative Biology Initiative, Harvard University, Cambridge, MA 02138, USA.
- 3NSF-Simons Center for Mathematical and Statistical Analysis of Biology, Harvard University, Cambridge, MA 02138, USA.
- 4Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
- 5Department of Physics, Harvard University, Cambridge, MA 02138, USA.
- ↵*Corresponding author. Email: mdesai{at}oeb.harvard.edu (M.M.D.); skryazhi{at}ucsd.edu (S.K.)
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Science 25 Oct 2019:
Vol. 366, Issue 6464, pp. 490-493
DOI: 10.1126/science.aay4199
