Cryo-EM structures of the human cation-chloride cotransporter KCC1

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Science  25 Oct 2019:
Vol. 366, Issue 6464, pp. 505-508
DOI: 10.1126/science.aay3129

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vol. 366 no. 6464 505-508

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  • Received for publication June 13, 2019
  • Accepted for publication September 26, 2019
  • .

Author Information

  1. Si Liu1,2,*,
  2. Shenghai Chang1,3,*,
  3. Binming Han4,*,
  4. Lingyi Xu1,5,
  5. Mingfeng Zhang6,
  6. Cheng Zhao1,6,
  7. Wei Yang6,
  8. Feng Wang7,
  9. Jingyuan Li4,,
  10. Eric Delpire8,,
  11. Sheng Ye2,5,,
  12. Xiao-chen Bai9,,
  13. Jiangtao Guo1,6,
  1. 1Department of Biophysics, Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
  2. 2Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China.
  3. 3Center of Cryo-Electron Microscopy, Zhejiang University School of Medicine, Hangzhou 310058, China.
  4. 4Zhejiang Province Key Laboratory of Quantum Technology and Device, Institute of Quantitative Biology, Department of Physics, Zhejiang University, Hangzhou, Zhejiang 310027, China.
  5. 5Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  6. 6Department of Biophysics, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  7. 7Wuxi Biortus Biosciences Co. Ltd., 6 Dongsheng West Road, Jiangyin 214437, China.
  8. 8Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  9. 9Departments of Biophysics and Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  1. Corresponding author. Email: jiangtaoguo{at} (J.G.); xiaochen.bai{at} (X.B.); sye{at} (S.Y.); eric.delpire{at} (E.D.); jingyuanli{at} (J.L.)
  1. * These authors contributed equally to this work.


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