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Science  25 Oct 2019:
Vol. 366, Issue 6464, pp. 523
DOI: 10.1126/science.366.6464.523

Breath Sampler and Portable Air Supply

Owlstone Medical introduces the ReCIVABreath Sampler and CASPER Portable Air Supply, designed to support internal biomarker discovery programs and those of academic and biopharma clients, and to measure levels of known volatile organic compounds (VOCs) on breath. CASPER features a range of benefits, such as uniting the airflow pump and filter into a single casing that connects directly to the ReCIVA Breath Sampler, the use of filter cartridges that can be easily replaced, and active warnings when the cartridges need changing or when temperature or airflow issues occur. In addition, we have implemented new software to monitor subject breathing and VOC collection through ReCIVA, including a simpler user interface and the ability to set different levels of access to settings for different users.

Human IgGκ Detection Kit

Sphere Fluidics offers the Cyto-Cellect Human IgGκ Detection Kit, to be used in conjunction with the Cyto-Mine Single Cell Analysis System for rapid, cost-effective measurement of antibody class and productivity in cell line development. The Cyto-Cellect Kit has been developed to provide Cyto-Mine users with a convenient, standardized assay format for the detection of secreted human antibodies in picodroplets. The sensitive, fluorescence resonance energy transfer (FRET)-based assay rapidly detects the presence of human immunoglobulin G (IgG) with kappa (κ) light chain after secretion from encapsulated cells, to characterize and measure antibody production. Rapid detection of IgG enables high-throughput identification and selection of cells with the highest productivity for more efficient cell line development. With optimized ratios of Sphere Fluidics' Human IgGK Detection probes, Cyto-Cellect offers a sensitive, robust assay ideal for streamlining cell isolation and titer determination. This animal-origin-free reagent kit delivers confidence in the reproducibility and consistency of the assay and conforms to regulatory requirements in cell line development.

Culture Media

FUJIFILM Irvine Scientific introduces the BalanCD Gal Supplement. This formula has been developed to increase galactosylation in biotherapeutic development, and to help achieve desired glycan profiles for improved product quality and antibody efficacy. Glycosylation is a critical aspect in development and optimization of protein-based therapeutics. The type and level of glycosylation can significantly affect antibody binding, function, and therapeutic efficacy. Galactosylation (the glycosylation of galactose) is a key method for controlling product quality due to its significant impact on antibody function, and the ability to control galactosylation levels through the cell culture medium. BalanCD Gal Supplement is a chemically defined, animal component–free formula designed to increase N-linked galactosylation with a scalable protocol, offering researchers a simple method to control the process through the cell culture medium. The supplement is effective at low concentrations and is compatible with any basal growth medium.

EV Targeting Kit

The XStamp Pro Streptavidin EV Targeting Kit gives you virtually unlimited target specificity options. Just decorate the outside of your extracellular vesicles (EVs) with XStamp Pro Streptavidin and then attach the biotinylated targeting moiety partner of your choice, such as a biotinylated single-chain variable fragment (scFv) antibody. Save time and simplify your EV engineering workflow with XStamp Pro. While conventional methods for creating target-specific EVs are highly robust, they involve cloning and manipulation of the producer cells, which can be challenging, especially if the cells are hard to transfect. To streamline this process and help researchers more quickly and easily create EVs that preferentially localize to a specific target, System Biosciences turned to an exciting new technology, XStamp Pro, which works on already purified EVs—no cloning or transfection required. Simply incubate purified EVs with the XStamp Pro reagent for 1 h and then isolate your target-specific EVs.

Confocal Objectives

Molecular Devices announces water immersion objectives as a high-performance customization for the ImageXpress Micro Confocal High-Content Imaging System. Water immersion objectives can offer signal increases of up to fourfold, which can help scientists see deeper into 3D and thick tissue samples at lower exposure times. These objectives also improve z-resolution and spherical aberrations; enable sharper, crisper images; and offer access to more data than ever before. The Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high-quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. Molecular Devices can successfully tailor the system to include customized software and hardware as well as integration of other lab components, such as incubators, liquid handlers, and robotics.

Miniature Solenoid Valve

The genvi solenoid valve provides outstanding application versatility and unmatched reliability at an economical price. One of the key objectives in developing the genvi solenoid valve was to challenge the limitations of current fluidic technologies by allowing designers to use a miniature, low-power solenoid valve without compromising system-level flow-rate requirements. As a result, the valve is capable of achieving minimum flow rates of 30 to 40 standard liters per minute (SLPM) at 15 psi differential (psid), and its spike-and-hold profile results in ultralow power consumption (318 mW) during continuous duty operation on air and compatible gas applications. These valves are designed to provide response times of less than 10 ms in applications with an operating temperature range from 40°F to 120°F. Typical applications for the valves include molecular diagnostics, oxygen delivery, environmental monitors, compression therapy, and breath analyzers.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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