Research Article

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

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Science  25 Oct 2019:
Vol. 366, Issue 6464, eaax6624
DOI: 10.1126/science.aax6624

Article Information

vol. 366 no. 6464

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  • Received for publication April 11, 2019
  • Accepted for publication September 12, 2019
  • .

Author Information

  1. Michael G. Constantinides1,
  2. Verena M. Link1,
  3. Samira Tamoutounour1,*,
  4. Andrea C. Wong2,
  5. P. Juliana Perez-Chaparro3,
  6. Seong-Ji Han1,
  7. Y. Erin Chen4,
  8. Kelin Li5,
  9. Sepideh Farhat6,
  10. Antonin Weckel6,
  11. Siddharth R. Krishnamurthy1,
  12. Ivan Vujkovic-Cvijin1,
  13. Jonathan L. Linehan1,,
  14. Nicolas Bouladoux1,3,
  15. E. Dean Merrill1,
  16. Sobhan Roy7,
  17. Daniel J. Cua8,,
  18. Erin J. Adams7,
  19. Avinash Bhandoola9,
  20. Tiffany C. Scharschmidt6,
  21. Jeffrey Aubé5,
  22. Michael A. Fischbach4,
  23. Yasmine Belkaid1,3,§
  1. 1Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
  5. 5Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  6. 6Department of Dermatology, University of California, San Francisco, CA 94143, USA.
  7. 7Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
  8. 8Merck & Co., Merck Research Laboratories, Palo Alto, CA 94304, USA.
  9. 9Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  1. §Corresponding author. Email: ybelkaid{at}
  • * Present address: L’Oréal Research and Innovation, Aulnay-sous-Bois, 93600, France.

  • Present address: Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.

  • Present address: Janssen Research and Development, Spring House, PA 19477, USA.


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Article usage: October 2019 to February 2020

Oct 20191032831991742
Nov 201919401394951
Dec 20191111435325
Jan 20201034433316
Feb 2020530222126

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