PerspectiveENZYMOLOGY

The immune system mimics a pathogen

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Science  01 Nov 2019:
Vol. 366, Issue 6465, pp. 574-575
DOI: 10.1126/science.aaz4540

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Summary

Microbes evolve diverse chemical strategies to survive in restrictive environments. Mycobacterium tuberculosis (Mtb) infection is a notable example of microbial persistence in a harsh milieu. Mtb causes tuberculosis (TB), a disease that kills more than 1.3 million people annually (1). On page 589 of this issue (2), Ruetz et al. describe how the immune system fights back against Mtb by stealing a page from the bacterial chemical warfare playbook.

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