Contents
15 November 2019
Vol 366, Issue 6467
Vol 366, Issue 6467
Special Issue
Quality control in the cell
Introduction
Reviews
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- A new form of pure carbon dazzles and attracts
Reflective, conductive, and magnetic, U-carbon could have many practical uses—if it's real.
- ‘Secret science’ plan is back, and critics say it's worse
EPA proposal would allow regulators to ignore many health studies.
- Bacterial toxin linked to severe alcoholic liver disease
In mice, viruses known as phages reduced alcohol-related liver problems by eliminating a gut microbe.
- Drones reveal earthquake hazards hidden in the abyss
Low-cost approach enables United States to double scrutiny of seafloor creep in quake zones.
- A mysterious disease is striking American beech trees
Researchers debate whether a tiny worm is to blame.
- Top Democrat wants big AI push
Senator Charles Schumer calls for 5-year, $100 billion plan.
Feature
- Life partners
Nancy Moran's passion for insects and their indwelling microbes helped the field of symbiosis come into its own.
- Arctic intruder
The Polarstern is enabling scientists to spend 1 year frozen in ice. Now, they must make sure the ship doesn't wreck their studies.
Working Life
Letters
Books et al.
- Returning the fallen
An anthropologist offers compelling context for ongoing efforts to repatriate service members killed in Vietnam
- The deadly diffusion of lethal technologies
From 3D-printed guns to weaponized hobby drones, open technologies pose sinister threats
Policy Forum
- China's key role in scaling low-carbon energy technologies
Meeting the Paris goals will require collaboration with China
Perspectives
- Translating translation in Down syndrome
Protein quality control mechanisms may hold the key to treatment of cognitive disability
- Modeling the early development of a primate embryo
Post-implantation embryos from cynomolgus monkeys are cultured for extended periods
- Cross-linking polyethylene through carbenes
A carbene-forming molecule can glue various polymers, even ones lacking functional groups
- Piling on the pressures to ecosystems
Identifying dangerous combinations of assaults could prevent ecosystem collapse
- Cellular survival over genomic perfection
DNA repair pathways permit some damage, leading to mutagenesis but not always cancer
- Overcoming glass brittleness
Thin films of flawless amorphous alumina are ductile at room temperature
- Reuniting biogeochemistry with ecology and evolution
Mining of biological and geochemical data pinpoints a key trait of freshwater plants
- Microbes and genes in heart failure
Human genetic variants and gut microbiota trigger cardiac inflammation
Research Articles
- Dissecting primate early post-implantation development using long-term in vitro embryo culture
A platform that can explore the characteristics and mechanisms of early postimplantation embryogenesis in nonhuman primates is described.
- In vitro culture of cynomolgus monkey embryos beyond early gastrulation
A platform that can explore the characteristics and mechanisms of early postimplantation embryogenesis in nonhuman primates is described.
- Structure of the RSC complex bound to the nucleosome
Cryo-EM analysis reveals the architecture of the yeast RSC chromatin remodeler complex bound to the nucleosome.
- Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
Correcting a protein network that regulates proteostasis reverses deficits in a mouse model of Down syndrome.
- Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells
Chains of platinum-nickel alloy nanocages with platinum-rich surfaces are efficient and robust oxygen reduction catalysts in fuel cells.
Reports
- Widely tunable compact terahertz gas lasers
Excitation of gas molecules with a quantum cascade laser provides a widely tunable source of terahertz radiation.
- Nano–opto-electro-mechanical switches operated at CMOS-level voltages
Combining opto-electro-mechanical effects with plasmonic devices enables CMOS-compatible optical networks.
- Highly ductile amorphous oxide at room temperature and high strain rate
Dense and flawless alumina glass can be viscously deformed without fracturing, unlike many similar ceramics.
- Electrical control of interlayer exciton dynamics in atomically thin heterostructures
Long-lived interlayer excitons are electrically generated and controlled in a MoSe2/WSe2 heterostructure.
- A broadly applicable cross-linker for aliphatic polymers containing C–H bonds
A rationally designed bis-diazirine can cross-link alkyl polymers.
- Catchment properties and the photosynthetic trait composition of freshwater plant communities
The geographical distribution of bicarbonate use in freshwater plants is controlled by catchment characteristics.
- Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Restraining cardiotoxic T cells through manipulation of the microbiome transforms inflammatory cardiomyopathy into a targetable disease.
- The role of multiple global change factors in driving soil functions and microbial biodiversity
A combination of global change factors can predict trends of ecosystem reactions, soil properties, and microbial communities.
- Generation of solar spicules and subsequent atmospheric heating
Solar spicules appear minutes after patches of reverse-polarity magnetic field, implying that magnetic reconnection occurs.
- Thermally condensing photons into a coherently split state of light
Photons cooled into a split Bose-Einstein condensate could be used as a quantum source of light.
Technical Comments
About The Cover
COVER Stylized view of the cell to illustrate that the nucleus exports RNA messages that are translated into proteins (blue) by ribosomes. Proteasomes and lysosomes degrade and recycle internalized, aberrant, or excess proteins. The endoplasmic reticulum and Golgi complex package and sort cargoes for transport to other organelles or for export from the cell. Mitochondria provide power to the rest of the cell. For more on cellular quality control, see page 816.
Illustration: Nigel Sussman
