PerspectiveDevelopment

Modeling the early development of a primate embryo

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Science  15 Nov 2019:
Vol. 366, Issue 6467, pp. 798-799
DOI: 10.1126/science.aaz6976

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Summary

Because mammalian embryos develop inside the uterus after implantation, they are practically inaccessible for direct observation and experimental analysis of the developmental process. To visualize and study the development of post-implantation embryos, it is necessary to develop a technology that maintains the viability and growth of embryos ex vivo in a controlled environment. This is especially the case for nonhuman primate embryos, which are likely to be adopted for modeling early human development. On pages 836 and 837 of this issue, Ma et al. (1) and Niu et al. (2), respectively, report in vitro culture methods for cynomolgus monkey embryos and demonstrate their utility for gaining insights into early primate embryo development.

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