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Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

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Science  22 Nov 2019:
Vol. 366, Issue 6468, pp. 1029-1034
DOI: 10.1126/science.aaw9886

Article Information

vol. 366 no. 6468 1029-1034

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 12, 2019
  • Accepted for publication October 25, 2019
  • .

Author Information

  1. Iván M. Moya1,2,*,
  2. Stéphanie A. Castaldo1,*,
  3. Laura Van den Mooter1,*,
  4. Soheil Soheily1,*,
  5. Leticia Sansores-Garcia1,
  6. Jelle Jacobs3,
  7. Inge Mannaerts4,
  8. Jun Xie1,
  9. Elisabeth Verboven1,
  10. Hanne Hillen1,
  11. Ana Algueró-Nadal1,
  12. Ruchan Karaman1,
  13. Matthias Van Haele5,
  14. Weronika Kowalczyk1,
  15. Maxime De Waegeneer3,
  16. Stefaan Verhulst4,
  17. Panagiotis Karras6,
  18. Leen van Huffel1,
  19. Lars Zender7,8,9,
  20. Jean-Christophe Marine6,
  21. Tania Roskams5,
  22. Randy Johnson10,
  23. Stein Aerts3,
  24. Leo A. van Grunsven4,
  25. Georg Halder1,
  1. 1VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.
  2. 2Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Americas, Quito, Ecuador.
  3. 3VIB Center for Brain and Disease Research and KU Leuven Center for Human Genetics, University of Leuven, Leuven, Belgium.
  4. 4Liver Cell Biology Research Group, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
  5. 5Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
  6. 6Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology and Department of Oncology, KU Leuven, Leuven, Belgium.
  7. 7Department of Medical Oncology and Pneumology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
  8. 8German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  9. 9iFIT Cluster of Excellence EXC 2180 “Image Guided and Functionally Instructed Tumour Therapies,” University of Tuebingen, Tuebingen, Germany.
  10. 10Department of Cancer Biology, Program in Cancer Biology, Graduate School for Biological Sciences GSBS, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  1. Corresponding author. Email: georg.halder{at}vib.be
  1. * These authors contributed equally to this work.

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Jan 20202247659338
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