29 November 2019
Vol 366, Issue 6469

About The Cover

Cover image expansion

COVER Nerve cells from the mouse brain, densely reconstructed in this volume. For a century, neuron reconstruction in the cerebral cortex showed only ~1 in 1000 nerve cells (black); now researchers can use 3D electron microscopy and AI-based image analysis to reconstruct all of them (gray). The connectivity matrix between thousands of axons and dendrites can be measured, yielding insights about the formational patterns of brain circuits and possible imprints of learning in the neuronal network. See page eaay3134.
Image: V. Altounian/Science; Data: A. Motta et al., Science 366, eaay3134 (2019)