Report

Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design

See allHide authors and affiliations

Science  29 Nov 2019:
Vol. 366, Issue 6469, pp. 1139-1143
DOI: 10.1126/science.aaw2900

Article Information

vol. 366 no. 6469 1139-1143

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 7, 2018
  • Accepted for publication November 5, 2019
  • .

Author Information

  1. Pierce J. Ogden1,2,3,*,
  2. Eric D. Kelsic1,2,4,*,,
  3. Sam Sinai1,2,4,5,
  4. George M. Church1,2,3,4,
  1. 1Harvard Medical School, Boston, MA 02115, USA.
  2. 2Wyss Institute for Biomedically Inspired Engineering, Boston, MA 02115, USA.
  3. 3Harvard Graduate Program in Biological and Biomedical Sciences, Boston, MA 02115, USA.
  4. 4Dyno Therapeutics, Inc., Cambridge, MA 02139, USA.
  5. 5Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  1. Corresponding author. Email: eric.kelsic{at}dynotx.com (E.D.K.); gchurch{at}genetics.med.harvard.edu (G.M.C.)
  1. * These authors contributed equally to this work.

Altmetric

Article usage

Article usage: November 2019 to June 2021

AbstractFullPdf
Nov 201977831512834
Dec 2019890933312028
Jan 20202972685458
Feb 20202363375190
Mar 20201481331212
Apr 20201156234217
May 20201692407359
Jun 2020998254188
Jul 2020735185150
Aug 2020750168139
Sep 2020965308162
Oct 20201365394266
Nov 2020884324187
Dec 2020198698447
Jan 20213471316798
Feb 20212631371791
Mar 20212211041675
Apr 2021202959584
May 20212371014553
Jun 202188493305

Stay Connected to Science

Navigate This Article