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Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design

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Science  29 Nov 2019:
Vol. 366, Issue 6469, pp. 1139-1143
DOI: 10.1126/science.aaw2900

Article Information

vol. 366 no. 6469 1139-1143

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History: 
  • Received for publication December 7, 2018
  • Accepted for publication November 5, 2019
  • .

Author Information

  1. Pierce J. Ogden1,2,3,*,
  2. Eric D. Kelsic1,2,4,*,,
  3. Sam Sinai1,2,4,5,
  4. George M. Church1,2,3,4,
  1. 1Harvard Medical School, Boston, MA 02115, USA.
  2. 2Wyss Institute for Biomedically Inspired Engineering, Boston, MA 02115, USA.
  3. 3Harvard Graduate Program in Biological and Biomedical Sciences, Boston, MA 02115, USA.
  4. 4Dyno Therapeutics, Inc., Cambridge, MA 02139, USA.
  5. 5Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  1. Corresponding author. Email: eric.kelsic{at}dynotx.com (E.D.K.); gchurch{at}genetics.med.harvard.edu (G.M.C.)
  1. * These authors contributed equally to this work.

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